I removed the spare tire and its crossmember. In case of a tire issue I carry a rope plug kit, starter fluid to re-bead and one of these in case of sidewall damage:
Full-Size Sidewall Kit - https://www.gluetread.com/products/full-size-kit
Save like 90 lbs and increase your clearance too. I don't carry a spare either, just the plug kit and a satellite radio, one of my homeboy will come get me haha