I sold my 2000 LC and bought an 04 Tundra doublecab, which is essentially a 1st gen Sequoia with a bed. I regret it every day. The Tundra, when judged on its own merit, is a fantastic truck. Mine has 165k miles, and I've never done anything but change the oil (bought with 120k).
However, when judged in comparison with the 100 it fails. It's nowhere near as comfortable. The seats in mine are manual and have limited adjustments. They flat out suck- it feels like I'm sitting on the floor. The interior is covered in hard plastic, which is very durable, but it doesn't feel nice like the 100. Its loud and unpleasant to drive above 60 mph. The sequoia may have more sound deadening but they are basically the same vehicle from the bed forward. Even the rear seat is interchangeable.
All that said, it's not a bad truck on its own merit, it just doesn't compare AT ALL to the 100, and I am currently looking for another 100 to replace it with.
To piggy back off an earlier post, we also have an 08 Sienna XLE. Bought it with 70k miles and now it has 145k. It's never had a problem other than chewing through tires at lightspeed. I also find it to be very loud at interstate speeds, and I don't find the seats to be particularly comfortable, although they are leather. It's a nice vehicle, but it's just an appliance.