Good news -- I managed to get the new PX6/Android 8.1 unit installed in my 2006 LX470 tonight. All of the harnesses were an exact match from the PX3/Android 6.0 unit that had been installed, so this time it was really just a matter of transferring the OEM black box over to the new radio and swapping the vents/buttons from the grey plastic side panels that came with the PX3 to the faux-cherry burl wood side panels that came with the PX6 unit. (They're a big improvement.)
Happy to report that all speakers and the subwoofer work perfectly; a rousing success all around. The PX6 is also blazingly fast compared to the decade-old PX3, which is over-matched by nearly all of today's "staple" apps like Waze, and pretty much all streaming video. If you're considering buying a PX3 unit to save a few bucks, don't. You will regret it immediately.
Anyway, here's a brief rundown of my initial impressions of the PX6 head unit; happy to get additional specific shots, if requested:
tl;dr - buy one.