Were you ever able to figure this out? My 2011 LC is showing very similar symptoms to yours. 211k miles.
- only the driver's door and rear hatch will unlock from the fob, driver door switch, individual door switches, or exterior button on rear hatch
- all doors will lock normally
- sometimes I get eight beeps in a row from the vehicle when trying to unlock/lock from the fob
- fuses seem to look good
- I played with the door lock settings in the nav unit, that didn't help
- when this first happened and again once after that my hazard flashers went on spontaneously/while I was starting the car
- the two codes I see when I scan the vehicle with Carly are for the HVAC Climatronic:
1. B1421 - Description is CD player operation fault but the CD player seems to work just fine
2. B1424 - Description is ECU internal fault but it is a malfunction in the Solar Sensor Circuit (Driver Side)
Edit: I just tried disconnecting the battery for 15-20 minutes and reconnecting. The problem persists. My suspicion is the same as yours, that the MAIN BODY ECU (COWL SIDE JUNCTION BOX LH) is faulty. I am going to try a couple more things before I work on removing it. Then I will confirm the part number if possible and order a new or used one. Or I will try to have mine fixed locally somehow, we have an old school electronics repair shop in town.
This problem seems to happen in other Toyota models more often, either due to a higher fault rate or higher production numbers. There is a guy on
eBay who sells a kit that will modify the ECU so that anytime the driver's door unlocks the other doors will trigger and unlock. This removes the functionality of unlocking only the driver's door but I don't use that function anyway. Otherwise, it solves the problem. I reached out to him but he didn't seem to have any interest in developing a kit for the LC200.
I did replace the windshield trim recently but I was especially careful on the driver's side, I don't think this is related. I still have to pull back trim and check for moisture but I am betting the recent cold weather has more to do with this.