No, core must be in place. Open HEATER valve to Hot. I have a heater hose duct taped to a cheap
plastic reducer from the 2” shop vac hose. Then I attach the blowing part to the heater inlet hose. Disconnect the heater outlet hose so it can drain into a bucket /floor whatever you are comfortable with. Turn the vacuum on and it will blow the fluid from the heater core completely. If you pour a flushing agent, rad flush, an extreme option is diluted muriatic acid, but this is caustic and you want to make sure you don’t leave any of that in there. You can flush the rad flush agent using a garden hose, but then blow it out again with the vacuum air pressure to remove all the water so the system is cleaned right out.
To make it easy when you reinstall everything, pour anti freeze using a funnel directly down into the heater so it’s full with just new antifreeze.
I flushed my 12HT engine block the same way, just blew vacuum pressure air into the heater return line. It makes sure all the old fluid is out. Last time I did this, I was within 100 ml of full of what the manual said it would hold when I refilled with new. So I knew the system was completely flushed.
BTW, I just spent 90 min tearing the entire interior and dash out. Next step is to find a leak that has filled the floors with antifreeze. I have no idea yet. The bottom of the heater box is dry.

Tomorrow should tell me what the heck is going on. I’m suspecting copper heater line connection but so far that’s not found out.