I just noticed this post while randomly searching for muffler info, so I joined to comment. Anyway. I have a 2000 Lexus LX470 237,000ish miles. Last spring had the same thing happen: 75mph, cruise control, air on, passing a truck on the highway about 2-1/2 hours into a 4-hour drive home. Instantaneous loss of power, then I hit the gas and just kept driving. No lights or anything. I would have doubted it even happened except my teenage son in the back seat was like 'what just happened?' Two weeks later when I went out to start it (it's my daily driver) it didn't start on the first turn and then on the second all my dashboard warning lights came on and stayed on but it ran fine. My mechanic ran the codes and came up with a Mass Air Sensor malfunction which he thought was really odd. I did a weekend trip, five hours there and back with no problems. A week later, I went to start it and my key just spun. I had to have it towed (to the dealer) and ended up having the steering column ignition bracket and assembly replaced ($800 ouch - but only slightly more than a new car payment right?). My mechanic thinks that the ignition mechanism was loose/failing and may have been the culprit in both cases. It's been fine all summer although no big trips. I drove to IF yesterday (1-1/2 hours each way) with no problem. Hopefully, that was the last of that issue (fingers crossed!).