I think the two factors for axles would be:
1. Engine HP and Torque
2. Tire size.
One can run a 4cyl mini truck with multiple cases and built toy axles and run 40's.
Add weight with a heavy truck things change.
Add HP and things get weaker.
Add larger tires and things get weaker.
Now you have added wheelbase ~115" is longer than an 80. You may have noticed, I added tire size when I added wheel base. (104"). I wheeled my 80 in Moab this past April on 35's. It did fine but I did not do hard trails. It is fully locked, geared and has RCV's. I would want more tire to do harder stuff. Hells was about as hard as we did.
Years ago when I put tons under my 4Runner, it was a game changer. I ran 37's first then 39 stickies. At a point it takes all the fun out of wheeling. It was brought up that running 7-10 level trails you need larger tires. When I built my STW I wanted something that would challenge me. Make me drive and pick lines. In my Racecar on 40" stickies, I can almost point and shoot. I think you need to ask yourself, Do you build something that will challenge you on 90% of the trails out there, or be bored on the basic trail and do 10% extreme trails.
If I can remember your build thoughts this is what I am gathering. Please let me know if I missed something.
40 based body
stockish 5.3 engine 300 hp
wheel base of 115"
Not too wide so it still looks like a 40
Good Road manors
reliable
My thoughts:
3 link front
4 link rear
No more than 12" travel shocks coilovers
80 axles RCV's, 4:88's, Chromoly rear and ARP everywhere (See Richards build

)
37" tires
OR
Tons and 40's with everything else the same
I do not plan to go larger than 35's on my Toyota axles nor do I plan to put my extra 6.0 LS in it UNLESS I put my set of tons under it and then it would go larger in tires and suspension. I like that the little tbi 350 makes enough HP, but not too much. I think the current drive train will hold up to most of my wheeling. Stock rear but have RCV's in the front axle.
As I am getting older, my 40 is easier to get in and out of compared to my race car. I plan to keep it for a long time. If I sold my race car, I may go larger in the 40, but it goes everywhere I want it to at the moment. I ran some hard trails last weekend, ended up on a RED for a short time but did not winch all weekend, two days of wheeling at the Cove. Most guys in my group where on 37's.