One follow-up. Took the wife to dinner last night and she noticed that the cab was quieter. I did have to point it out on the way to dinner, but she did confirm on the way home. So this might be a worthy item to replace if it's been 25 years since they were freshened up :)
Changed the front drivers and passenger door weather strips. They were 27 years old so I'm sure it was time. I can actually tell a difference in volume driving down the road. I should have ordered them for the back doors also!