I have a 2010 460 and took the 1.25" Kuat NV 2.0 Base I was using on my Subaru before buying the truck. With a 2" -1.25" hitch adapter, the rack works great, however I think that the 1.25" Kuat has a big gooseneck on the rack that raises the whole tray up, great for lower cars, but bad for ours. With no bikes on the rack, I can't open the door more than a few inches.
Based on parking lot assessment of other racks, seems like the majority of 2" hitch racks will sit low enough to be able to open the door with no bikes on it. I'm sure the door is inaccessible with bikes on the rack as others have noted. And you can always use the window.