Let's get some meter basics down - skip if you already know this. I am an EE/electronics designer with over 30 years in the biz, so this stuff is like breathing to me.
Note 1: in DC V (volts) mode, the meter acts like a very high resistance ( an open switch or open circuit) in parallel to the circuit you are measuring. The meter is connected in parallel to the item under test (recall voltage across parallel loads is the same for all loads).
Note 2: In DC A ( or mA) current mode, the meter acts like a piece of wire - a short circuit (also called closed circuit or closed switch). This is why you never connect a meter in current mode across your battery! If you connected a wire across the battery what happens? Fire! To measure current, you "break" the conductor you want to measure the current in, and the meter goes in SERIES with the "break". An easy was to "break" a circuit is to pull the associated fuse.
Measuring current in the suspect circuit is only a start to pinpoint a leak. Recall in DC Voltmeter mode, the meter acts like a very high resistance in parallel with whatever the probes are touching. If you, for example, pull the fuse for a suspect circuit and put the voltmeter (in DC V mode) across the two terminals, and it measures 12 V, then there is a leak to ground somewhere that is much less resistance than the meter itself, by the voltage divider rule. If you measure 6V, for example, then the leak resistance is the same as the meter (in this case, I wouldn't worry too much as the meter input resistance is so high it wouldn't be a significant drain.) Typically if there is a leak or load you will measure 12V. If you get 0V, then there is no path to ground - no leak. Once you find the leaky circuit, you can switch meter mode (and probes) to DC A mode and again go across the removed fuse terminals (or opened wire) to measure the actual leakage current.
Now recall that even when off, things like stereo, clocks, and such still have a slight current draw which is normal. You may have to disconnect these things when troubleshooting to get them "out of the circuit". In the case of the dome light circuit, there are many paths to ground. On the drawing you will see, for example, 4 door switches in parallel so that if any one (or more) of them are closed, the light comes on. You have to use your head and the drawing to see what all is a possible path to ground. In the Toyota, the ground wires are routed to various points on the body and frame where they are screwed in. You may have to locate these and temporarily unscrew them one at a time to figure out where the problem is, which is usually a bad or incorrect connection. The FSMs have this info, and the schematics are drawn so that 12V is at the top and flow down to grounds at the bottom.
In every used vehicle I have ever owned, I find electrical things that were added, repaired, or modified in a crappy manner, with no heat shrink, twisted together with black or duct tape, and often connected WRONG. I always suspect this stuff first. For example, when I re-did my FJ60's trailer connector wiring recently, I found a horrendous rat's nest of bad connections that was done by retarded spider monkeys. I ripped it all out, repaired the stock wiring, and then installed a new wiring kit properly. Same with stereos and aux panels added by a PO - look upon that stuff with a jaundiced eye.
Hope this helps. If you were in the neighborhood I would come over and help, but all I can do is be a sage and a cheerleader on the internet. Keep at it in a methodical manner until you find the problem. Disconnect non-stock stuff. If you are SURE everything is correct and you still have a problem, then something you are SURE is correct is, in fact, incorrect. Good luck.