I've replaced three of the five sets on each side (#2 -#4) and it does make a difference. I'm still trying to figure out how the remove the screws on #5, but it's on the list for this weekend. There's only about an inch of clearance between the busing and the little hat section bracket that "retains" it, so I'm not entirely sure how to get at it. There are frame access holes more or less under them, but they don't line up on my body. I ordered replacement screws, just in case I eat them up getting them out (or trying to do so).
I have a feeling it won't make much difference, until there's a load in the cargo area. Replacing those, along with all four shocks, made a noticeable difference in ride quality.
I didn't replace the front pair because only one was available at the time I ordered them (I bought them from PartSouq) and I didn't have the rear numbers for the HDJ bushings at the time, but both are on the list for near future installation.
FWIW, I'd also recommend adding the hollow pins (that protect the bushings from the mounting bolts, to your shopping list. Three of mine were usable, but the rest had significant rust on them, despite the rust preventative coating. I cleaned them as best I could, without significantly reducing the diameter, lightly coated them with Vaseline, and put them back in, but I wasn't really happy about it. I may go back an replace them when I put the corner bushings in. It's fairly painless; getting the upper bushings in is the only work you're doing.
My bolts were all in good shape, less the exposed thread areas, which I wasn't really concerned with, so I'm not repalcing any of them, but they also can be repalced ay any time, with only the effort of peeling back the carpet being required. I may replace the corner bolts, though, since they aren't hidden inside the body and protected from the elements.
HTH