that all depends. sure, the 4 bolt boxes are stronger than the 3 bolt models but what's more important is that you want the 4.25 turn box, not the 3.5
the tire seize and how the vehicle is used will make a big difference as to which box ( 3 or 4 bolt ) you want. if the rig is tock/semi-stock and still sprung under on 33s or less, then you can get away with the 3bolt box. anything bigger than that and i'd run he 4 bolt and nothing else.
steering geometry has more to do with it than the # of bolts holding the box on.
fwiw, i can get you a decent deal on a reman box if you want one rob. i have them in stock at all times. 4 bolt, 4.25 turn.