The benefits to some domestics is upgraded parts bolt right on almost. It's not unheard of to see a ramcharger with a 5.9 cummins swapped in. It's quite easy to swap in axles that are beefy. You often have many near bolt in upgrades in regards to engines and drivetrains.
The American trucks are full sized type trucks, so they are harder to get on tight trails. That said I'd have no problem building a overlander out of one of those above.