Admittedly it's been a couple years since I was fluent in wheelspeak, but...
...to your first point, the diff between 3.77" and 4.5" is a significant change of center line between the two wheel bearings on the hub.
And hang on...offset is a cumulative difference in center-line, relative to...
OK then, lets talk about the -44 offset. lol
That's huge. What is the back space?
Main concern would be where the center line of the wheel ends up relative to the center line of the wheel bearing.
It's not an immediate issue, but it will cause accelerated wear on the bearings over time.