A buddy of mine moved to AK (a little north of Eagle River) a while ago. My dad and I went to visit him 3 years ago. During part of that trip we spend 10 days on the Dalton highway. It was by far the best trip of my life.
We ran into one guy that when through 3 tires just on the way up. Granted he did have a camper in the bed of his truck. Our truck had POS road tires that were all eaten up and some how we managed to get by with out any flats. I think it depends a lot on your driving style. As far as gas goes, at the time it was $3.50 or so a gallon in Prudhoe Bay. I’m sure it a whole lot higher today. The furthest you have to go between fill ups is 240miles between Cold Foot and Dead Horse (Prudhoe Bay).
Here a pic of the road at its best. The worst parts are
comparable to old forest service roads. We never used 4wd.
Night was this for 3 hours
Musk ox

Grayling
Sagwan River
Hunting ptarmigan with bows is great sport.
Wild fires
The Pipeline generally follows the Dalton highway. Some times is a mile or so away.
Yukon